Direct Measurement of Specific Interactions between Nucleic Acid Base Pairing.

Metal-mediated base pairing within the simplified nucleic acid GNA.

Hydroxypyridone and pyridopurine homo- and hetero-base pairs have been investigated in the context of duplex GNA (glycol nucleic acid). Phosphoramidites for automated GNA solid phase synthesis were synthesized economically in a few steps starting from commercially available enantiopure glycidol. Similar to their behavior in DNA, the hydroxypyridone and pyridopurine homo-base pairs display a met...

Fluorescent nucleic acid base analogues.

The use of fluorescent nucleic acid base analogues is becoming increasingly important in the fields of biology, biochemistry and biophysical chemistry as well as in the field of DNA nanotechnology. The advantage of being able to incorporate a fluorescent probe molecule close to the site of examination in the nucleic acid-containing system of interest with merely a minimal perturbation to the na...

Acid-base Interactions 10.1 GENERAL CONCEPT OF ACID-BASE INTERACTIONS

Acid-base interactions have found numerous applications in research dealing with adsorption of molecules of liquids on the surfaces of solids. The main focus of this research is to estimate the thermodynamic work of adhesion, determine mechanism of interactions, analyze the morphology of interfaces and various surface coatings, develop surface modifiers, study the aggregation of macromolecular ...

Backbone-base inclination as a fundamental determinant of nucleic acid self- and cross-pairing

The crystal structure of the duplex formed by oligo(2',3'-dideoxy-beta-d-glucopyranosyl)nucleotides (homo-DNA) revealed strongly inclined backbone and base-pair axes [Egli,M., Pallan,P.S., Pattanayek,R., Wilds,C.J., Lubini,P., Minasov,G., Dobler,M., Leumann,C.J. and Eschenmoser,A. (2006) Crystal structure of homo-DNA and nature's choice of pentose over hexose in the genetic system. J. Am. Chem....

Metal/Nucleic-Acid Interactions